Basic Science and Clinical Practice
Post-traumatic stress disorder is a psychiatric illness that can occur in anyone who has experienced a life-threatening or violent event. This title outlines the neurobiology of post-traumatic stress disorder and provides treatment strategies for clinicians.
Post-traumatic stress disorder is a psychiatric illness that can occur in anyone who has experienced a life-threatening or violent event. The trauma can be due to war, terrorism, torture, natural disasters, violence, or rape. In PTSD the brain areas that are likely to be affected are the hippocampus (memory), amygdala (fear association), the prefrontal cortex (cognitive processing), and the ascending reticular activating system (arousal). The chemical of interest is norepinephrine, which is released during a stressful event and is part of the fight-or-flight response meant to mobilize the body to action. The objective of this title is to outline the neurobiology of post-traumatic stress disorder and provide treatment strategies for clinicians. The chapter material from this book has evolved from a seminar on PTSD held recently under the auspices of the VA Boston Healthcare System, Boston University Medical Center and Harvard Medical School. We propose a book that will focus on the epidemiology, neurobiology, MRI studies, animal models, arousal and sleep issues, clinical trials, and treatment strategies for clinicians.; Treatment will cover such topics as guidelines for treating posttraumatic stress disorder, PTSD and the use of mental health services, cognitive intervention therapy, and large scale clinical trials in PTSD. This collection will be a vital source of information to clinicians and neuroscientists.
Post-traumatic Stress Disorder: Definition, Prevalence, and Risk Factors Terence M. Keane, PhD, Brian P. Marx, PhD, and Denise M. Sloan, PhD Amygdala and Fear Amygdala and the Neural Pathways of Fear Jacek Debeic, MD, PhD, MPhil and Joseph E. LeDoux, MD Physiology Of The Amygdala: Implications For Post-Traumatic Stress Disorder Donald G Rainnie, PhD and Kerry J. Ressler, MD, PhD Counteracting Molecular Pathways Regulating The Reduction Of Fear: Implications For The Treatment Of Anxiety Diseases Andre Fischer, PhD and Li-Huei Tsai, MD, PhD Memory In Post-Traumatic Stress Disorder: A Neurocognitive Approach Mieke Verfaellie, PhD and Jennifer J. Vasterling, PhD Animal Models of Post-Traumatic Stress Disorder Towards Animal Models of Post-Traumatic Stress Disorder Hagit Cohen, PhD and Gal Richter-Levin, PhD Post-Traumatic Stress Disorder: From Neurons to Networks Rajnish Rao, PhD, Aparna Suvrathan, Melinda M. Miller, Bruce S. McEwen, PhD, and Sumantra Chattarji, PhD Post-Traumatic Stress Disorder and Arousal Arousal Neurons in the Brain Priyattam J. Shiromani, PhD and Carlos Blanco-Centurion, PhD Hyperarousal and Post-Traumatic Stress Disorder: A Role for the Hypercretin System Matt Carter, B.Sc and Luis deLecea, PhD The Locus Coeruleus-Noradrenergic System and Stress: Implications for Post-Traumatic Stress Disorder Craig Berridge, PhD Effect Of Stress On Sleep And Its Relationship To Post-Traumatic Stress Disorder Larry D. Sanford, PhD and Xiangdong Tang, PhD Stress hormones in post-traumatic stress disorder Stress Hormones And Post-Traumatic Stress Disorder Rachel Yehuda, PhD Low Basal Cortisol And Startle Responding As Possible Biomarkers Of Post-Traumatic Stress Disorder: The Influence Of Internalizing And Externalizing Comorbidity Mark W. Miller, PhD, Erika J. Wolf, MA, Laura Fabricant, BA, and Nathan Stein, PhD Brain Imaging in Post-Traumatic Stress Disorder Functional Neuroimaging In Post-Traumatic Stress Disorder Israel Liberzon, MD and Sarah N. Garfinkel, PhD The Amygdala in Posttraumatic Stress Disorder Lisa Shin, PhD Treatment Strategies Pharmacological Treatment Of Post-Traumatic Stress Disorder Murray Raskind, MD Guided Imagery as a Therapeutic Tool in Post-traumatic Stress Disorder Jennifer Strauss, PhD, Patrick S. Calhoun, PhD and Christine E. Marx, MD, MA 18. Virtual Reality Exposure Therapy for Combat Related Post-Traumatic Stress Disorder Albert Rizzo, PhD, Greg Reger, PhD, Greg Gahm, PhD, JoAnn Difede, PhD and Barbara O. Rothbaum, PhD, ABPP