Discusses the effect of fluorine in spectroscopy. This book describes the impact of fluorine substituents on proton and carbon NMR. It is suitable for a practicing organic chemist in interpreting spectroscopic data for molecules containing fluorine.
"Handbook of Fluorine NMR for Organic Chemists" provides a single one-stop resource for understanding fluorine and its dramatic effect in spectroscopy. Covering fluorine NMR, as well as the impact of fluorine substituents on proton and carbon NMR, this useful guide can provide the practicing organic chemist with an understanding of how to interpret spectroscopic data for molecules containing fluorine to better characterize their compound's structure. A practical, working guide, this book contains numerous examples of structures and their corresponding fluorine NMR shifts, as well as the effect that fluorine has on proton and carbon NMR shifts.
Preface. Chapter 1: Introduction. 1.1 Why fluorinated compounds are interesting. 1.2 Introduction to fluorine NMR. Chapter 2: An overview of fluorine NMR. 2.1 Chemical shifts. 2.2 Spin-spin coupling constants to fluorine. 2.3 1H NMR spectra of fluoroorganic compounds. 2.4 13C NMR spectra of fluoroorganic compounds. Chapter 3: The single fluorine substituents. 3.1 Saturated hydrocarbons with a single fluorine substituent. 3.2 Influence of substituents/functional groups. 3.3 Carbonyl functional groups. 3.4 Nitriles. 3.5 Alkenes with a single fluorine substituents. 3.6 Allylic, propargylic and benzylic fluorides. 3.7 Fluoroaromatics. 3.8 Fluoroheterocycles. 3.9 Other common groups with a single fluorine substituent. Chapter 4: The CF2 group. 4.1 Saturated hydrocarbons containing a CF2 group. 4.2 Influence of substituents/functional groups. 4.3 Carbonyl functional groups. 4.4 Nitriles. 4.5 Bifunctional CF2 compounds. 4.6 Alkenes and alkynes. 4.7 Benzenoid aromatics bearing a CF2 group. 4.8 Heteroaromatics. Chapter 5: The trifluoromethyl group. 5.1 Saturated hydrocarbons bearing a CF3 group. 5.2 Influence of substituents/functional groups. 5.3 Carbonyl compounds. 5.4 Nitriles. 5.5 Bifunctional compounds. 5.6 Sulfonic acid derivatives. 5.7 Allylic and propargylic trifluoromethyl groups. 5.8 Aryl-bound trifluoromethyl groups. 5.9 Heteroaryl-bound trifluoromethyl groups. Chapter 6: Compounds and substituents with fluorine directly bound to heteroatoms. 6.1 Boron fluorides. 6.2 Fluorosilanes. 6.3 Nitrogen fluorides. 6.4 Phosphorous fluorides. 6.5 Oxygen fluorides (hypofluorites). 6.6 Sulfur fluorides. 6.7 The pentafluorosulfanyl (SF5) group. 6.8 Aryl bromine and iodine tetrafluorides. 6.9 Xenon difluoride.