Designing artificial systems with catalytic efficiencies to rival those of natural enzymes is one of the great challenges. Suitable for students and senior researchers, this title presents an introduction to the area of artificial enzymes. It offers a systematic review of the key properties of natural enzymes.
Designing artificial systems with catalytic efficiencies to rival those of natural enzymes is one of the great challenges facing science today. This introduction to the exciting area of artificial enzymes is suitable for both students and more senior researchers. It starts with a systematic review of the key properties of natural enzymes. This is followed by a summary of the mechanisms involved in the major classes of reactions and a logical progression to the first, rudimentary artificial enzymes catalyzing them. An analysis of the classical design-based approach to catalysis by enzyme mimics leads on to a summary of recent advances in creating and improving catalysts. Key data interpretation skills are introduced in a guided approach that links kinetic measurements with their chemical and biological interpretation.
From Models, Through Mimics, to Artificial Enzymes; Evaluation of Catalytic Efficiency in Enzymes and Enzyme Models; Constructing Enzyme Models - Building Up Complexity; Enzyme Models Classified by Reaction; Design vs. Iterative Methods - Mimicking the Way Nature Generates Catalysts.