Discover, Development, and Manufacturing
Discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. This book emphasises on industrial applications and provides an introduction to the biocatalysts, modern expression hosts, directed evolution, high throughput screening, and bioprocess engineering.
Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, "Biocatalysis for the Pharmaceutical Industry" concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. It covers a wide range of topics in a systematic manner with an emphasis on industrial applications and provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering. It addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs.; It highlights the impact of biocatalysis on green chemistry and contains numerous graphics to illustrate concepts and techniques. "Biocatalysis for the Pharmaceutical Industry" is an essential resource for scientists, engineers, and R
1. Enzymes and Their Synthetic Applications: An Overview 2. Expression hosts for enzyme discovery and production 3. Directed Enzyme Evolution and High Throughput Screening 4. Applications of reaction engineering to industrial biotransformations 5. Chiral synthesis of pharmaceutical intermediates using oxynitrilases 6. Expanding the Scope of Aldolases as Tools for Organic Synthesis 7. Synthetic Applications of Ketoreductases and Alcohol Oxidases 8. Applications of Nitrile Hydratases and Nitrilases 9. Biosynthesis of drug metabolites 10. Application of Whole Cell Biotransformation in Pharmaceutical Industry 11. Combinatorial Biosynthesis of Pharmaceutical Natural Products 12. Metabolic engineering for the development and manufacturing of pharmaceuticals 13. Multimodular Synthases and Supporting Enzymes for Chemical Production 14. Green Chemistry with Biocatalysis for Production of Pharmaceuticals